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Tracxn – Healthcare Newsletter # 32 – Medical Devices

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A daily newsletter summarizing recent activity & interesting startups globally

RECENT NOTABLE ACTIVITY – MEDICAL DEVICES

  • TransMedics, a developer of organ transplantation technology, raises $51.2M in a Series F round led by Fayerweather Fund, Pharmstandard International S.A. represented by InBio Ventures, Ervington Investments, BioStar Ventures, Abrams Capital, Lung Biotechnology PBC, Flagship Ventures and KPCB. Link
  • Autonomic Technologies, develops neurostimulation system for severe headaches, raises $48.2M in a Series D round led by Edmond de Rothschild Investment Prtner. Link
  • Mitralign, a developer of cardiac valve repair device, raises $39.8M in a Series E round. Link
  • Sonendo, develops dental surgery equipment for root canal therapy, raises $33.27M in a Series E round. Link
  • OptiScan Biomedical, developing glucose monitoring systems for ICUs/CCUs, raises $29.47M in a Series C round. Link
  • EarlySense, developing contact free patient monitoring solution, raises $25M in a Series G round led by Bank Hapoalim. Link
  • Aleva Neuro, develops implantable Deep Brain Stimulation systems that enables therapies for neurological diseases, raises an $18M in a Series C round led by Greatbatch. Link
  • Titan Medical, develops a surgeon-controlled robotic surgical system for MIS, raises $16M in a PE round led by Shanghai Jugu Equity Investment Fund. Link
  • Flowonix, develops implantable drug delivery pump, raises $10.5M in a Series F round led by Shanghai Jugu Equity Investment Fund. Link
  • Biovotion AG, develops wearable vital sign monitoring, raises $10.39M in a Series A round led by  Swiss Re. Link
  • Aqueduct Neurosciences, develops implantable shunt to treat hydrocephalus, raises an $6.78M in a Series A round. Link

SOME INTERESTING STARTUPS FOUND

Open Bionics (2014, Bristol) – 3D prints low cost robotic prosthetic hand.

LEADER BOARD – MEDICAL DEVICES

THERAPEUTICS
Cardiovascular
TriVascular (1998, Santa Rosa, IPO) – Medical devices for endovascular aortic repair. Went public in 2014.
JenaValve (2006, Munich, $144M) – Transcatheter stents and delivery systems for transapical and transfemoral delivery. Backed by Atlas Venture, Edmond de Rothschild, NeoMed, Sunstone Capital, Gimv, Legend Capital, Omega Funds and Valiance.

Orthopedics
ConforMIS (2004, Bedford, IPO) – Personalized, partial knee resurfacing implants to treat knee osteoarthritis. Went public in 2015.
Small Bone Innovations (2009, Morrisville, $171M) – Suite of orthopedic products for small bones and joints. Backed by Trevi Health Ventures, Goldman Sachs, Malaysian Life Sciences Capital Fund, NGN Capital, Viscogliosi Brothers, Axiom Ventures, Khazanah Nasional Berhad, 3i Group.

Surgery

Auris Surgical Robots (2009, San Carlos, $184M) – Robotic microsurgical systems for ophthalmic surgery. Backed by NaviMed Capital, Lux Capital, Mithril Capital Management and Highland Capital Partners.
Medrobotics (2011, Raynham, $140M) – Robotic surgical devices for minimally invasive surgery. Backed by Hercules Technology Growth Capital and Pittsburgh Life Sciences Greenhouse.

Ophthalmology
TearScience (2005, Morrisville, $151M) – Diagnosis and Treatment of Evaporative Dry Eye. Backed by Spray Venture Partners, Essex Woodlands Health Ventures, eneralcatalyst.com, HealthCare Royalty Partners, Investor Growth Capital, DeNovo Ventures and Quaker BioVentures.
Avedro (2007, Waltham, $130M) – Corneal cross-linking technology. Backed by Interwest, OrbiMed Advisors, Prism Venture Management, DeNovo Ventures, Flagship Ventures, Aperture Venture Partners, SCP Vitalife Partners, Borealis Ventures, Abingworth, Third Point, and Prism Venture.

DIAGNOSTICS
Platform Technologies
Butterfly Network (2011, Guilford, $100M) – Medical imaging devices using a combination of deep learning and an ultrasonicdevice. Backed by Aeris Capital.
NinePoint Medical (2008, Bedford, $98M) – Optical coherence tomography based imaging system to perform volumetric laser endomicroscopy. Backed by Third Rock Ventures and Prospect Venture Partners.

Oncology
Impedimed (1999, Carlsbad, $106M) – Bioimpedance Spectroscopy technologies. Backed by Versant Venture Management, Starfish Ventures.
Veran Medical (2005, St.Louis, $66M) – Soft tissue navigation for diagnosis of lung cancer. Backed by Prolog Ventures, Versant Ventures, River Cities Capital Funds, Advantage Capital Partners, Rex Health Ventures, 3G Capital Partners and Vectis.

Infectious Disease
Accelerate Diagnostics (2004, Tucson, IPO) – In vitro diagnostics to provide solutions for the antibiotic resistant infections. Went public in 2013.
Curetis (2007, Holzgerlingen, $85M) – Molecular diagnostics POC device for infectious diseases. Backed by Forbion, KfW Bankengruppe, HBM Partners, BioMedPartners, CD-Venture GmbH, Roche, Qiagen, Life Sciences Partners, Aeris Capital.
MONITORING
Diabetes
OptiScan Biomedical (1994, Hayward, $156M) – Glucose monitoring systems for ICUs/CCUs. Backed by yet2Ventures, Mitsui, Medven, Lightstone Ventures, Oakwood Medical, Ascension Ventures, NGN Capital, Signet Healthcare Partners, Mitsui, Hercules Technology Growth Capital, Prism Venture, EGS Healthcare Capital Partners, Morgenthaler.

Senseonics (1996, Germantown, $124M) – Implantable system for continuous glucose monitoring. Backed by NEA, HealthCare Ventures, Rho Capital Partners, Anthem Capital Management, Delphi Ventures and Greenspring Associates.

Cardiovascular
CardioMEMS (2001, Atlanta, $153M, Acq.) – Wireless sensor-based implants for cardiac monitoring. Acquired by St. Jude Medical in 2014.
iRhythm Technologies (2006, SF, $95M) – Cardiac rhythm monitoring devices. Backed by Mohr Davidow Ventures, Synergy Life Science Partner, Novo A/S, Norwest Venture Partners, California HealthCare Foundation, Stanford University, Kaiser Permanente Ventures, New Leaf Venture Partners and New Leaf Ventures.Vital Signs
EarlySense (2004, Ramat Gan, $85M) – Contact free patient monitoring solution. Backed by Noaber, Bridge Investment Fund, Samsung Venture Investment Corporation, Docor, ProSeed, Pitango VC, Israel, Mitsui & Co, JK&B Capital, Bank Hapoalim, Welch Allyn, Challenge.

Sotera Wireless (2004, San Diego, $68M) – In hospital patient monitoring device. Backed by Sanderling Ventures, Qualcomm Ventures, Intel Capital, EDB Investments, Safeguard, Delphi Ventures, Cerner Capital, West Health and Sanderling.PLATFORM TECHNOLOGIES
Mannkind Corporation (1991, LA, IPO) – Biopharma company focusing on the discovery, development, and commercialization of therapeutic products for diseases such as diabetes and cancer. Went public in 2004.
Intarcia Therapeutics (1997, Boston, $886M) – Osmotic pump for subcutaneous drug delivery. Backed by New Leaf Venture Partners, Venrock, New Enterprise Associates, RA Capital Management, Farallon Capital Management, Foresite Capital, Fred Alger Management, Quilvest Ventures, Alta Partners, GGV Capital, New Leaf Ventures, Quilvest and Omega Funds.

CLINICAL EQUIPMENT
TransMedics (1998, Andover, $252M) – Organ transplantation technology. Backed by Tudor Funds, Abrams Capital, Flagship Ventures, Kleiner Perkins, Foundation Capital, Sagamore, Hercules Technology Growth Capital, Alta Partners, Sherbrooke Capital, VantagePoint Capital Partners and i Group plc.
Caesarea Medical Electronics (1993, Caesarea, $100M) – Infusion and syringe pump systems and accessories. Backed by CareFusion.

SUPPORT SYSTEMS
Ekso Bionics (2005, Richmond, IPO) – Bionic exoskeleton for people with paralysis. Went public in 2014.
BionX Medical (2007, Bedford, $75M) – Prosthetic device to aid movement of lower-limb amputees. Backed by Sigma Partners, General Catalyst, WFD Ventures and Gilde Healthcare.

MEDICATION MANAGEMENT
Proteus Digital Health (2001, Redwood City, $404M) – Medical adherence monitoring system. Backed by Asset Management Ventures, Medtronic, Carlyle, Fletcher Spaght, ON Semiconductor, SJM Telephony Svcs, Spring Ridge Ventures, ITOCHU International Inc., Adams Street Partners, Novartis, Oxford Finance Corporation, Essex Woodlands Health Ventures, Silicon Valley Bank, Oracle Corporation, Otsuka America Pharmaceutical and Kaiser Permanente Ventures.

For latest updates, visit the Medical Devices feed.


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